Instruct PartnerThe Protein Structure Determination in Industry Meeting will be held 8-10 November 2021. Bringing together experts in structural biology – both in research and in industry – the virtual webinar event features a number of speakers from several Instruct-ERIC centres.
The webinar has an extensive programme, covering: Cryo-EM, Artificial Intelligence, crystallography, integrative structural biology techniques, data management, and case studies
View the webinar programme below
MONDAY - 8TH NOVEMBER 2021
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Workshop 1
Cryo-EM (facilities, sample preparation, data collection and processing etc.)
Confirmed speakers: Marta Carroni, SciLifeLab, Sweden: "Facilitating accessibility to cryo-EM – The Swedish cryo-EM facility"
Andreas Schenck, Novartis, Switzerland: "Streamlining data collection and analysis for cryo-EM based structure determination"
Mathieu Botte, leadXpro, Switzerland: "Pro-Macrobodies: A new facilitator for high resolution cryo-EM structure determination"
Michael Saur, Astex, UK
15:30 - 16:00 Break 5 Mins / sponsor Talks / Videos
16:00 - 17:30 Session 1
AI opportunities in SBDD
Confirmed speakers: Lewis Mervin AZ, UK and Ola Engkvist, AZ, Sweden: "Privacy preserving machine learning in the pharmaceutical industry"
Ilaria Ferlenghi, GSK, UK: “GEMINI: an integrated structure and AI based approach for new vaccine identification”
Lovisa Holmberg Schiavone and Aurelie Bornot, AZ, Sweden: "A pre-competitive consortium to share data and build predictive models for recombinant protein expression" including subsequent panel discussion
17:30 - 18:15 Keynote Lecture
TUESDAY - 9TH NOVEMBER 2021
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Workshop 2
Automation and method development in crystallography
Confirmed speakers: Joachim Diez, Expose, Switzerland: "Never waste a good crisis“ - how the rise of Cryo-EM and the cumulative synchrotron dark times can lead to quality of life improvements for industrial MX-users"
Irina Cornaciu, ALPX, France: "Automated crystallography pipelines for small-molecule screening and membrane proteins "
Romain Talon, ESRF, France: "How ESRF MxPress workflows with automated decision-making make your data collection session more comfortable"
15:30 - 16:00 Break 5 Mins / Sponsor Talks / Videos
16:00 - 17:30 Session 2
Integrative Structural Biology
Confirmed speakers: Taiana Maia De Oliveira, AZ, UK: "Cryo-EM and Integrative Structural Biology at AstraZeneca“
John Briggs, MRC, UK: "In virus structural biology of SARS-CoV-2 and other viruses“
Juri Rappsilber, TU-Berlin, Germany: "In-cell integrative structural biology of transcription-translation coupling"
Dmitri Svergun, EMBL-Hamburg, Germany: "Integrative studies with solution X-ray scattering"
17:30 - 18:15 Virtual EMBL and ESRF Facility Tour
WEDNESDAY - 10TH NOVEMBER 2021
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Session 3
Structural Biology Data Management in the Big Data Era
Confirmed speakers: Raphael Bourgeas, EMBL, France and Clemens Vonrhein, Global Phasing Ltd, UK: "Integrated data tracking and analysis along the crystallography experimental workflow"
Robbie Joosten, NKI, The Netherlands: „Speeding up the last mile of structure solution with PDB-REDO“
Mihaly Varadi, EBI, UK: "PDBe-KB: An integrated knowledge base of molecular structures and their functional annotations that supports large scale data mining"
15:30 - 16:00 Break 5 Mins / Sponsor Talks / Videos
16:00 - 17:30 Session 4 Case studies
Confirmed speakers: Frank von Delft, University of Oxford, UK: "Systematic progression of fragments by linking AI and experiment by robotics"
Jan Steyaert, Vrije Universiteit Brussel, Belgium: "From Nanobodies to Megabodies for applications in cryo-EM“
Rob van Montfort, ICR, UK: “Achieving in vivo target depletion through the discovery and optimization benzimidazolone BCL6 degraders”
Markus G. Rudolph, Roche, Switzerland: “Selective DDR1 over DDR2 inhibitors from efficient screening and structure-guided design”
17:30 - 18:15 Poster session
