We have applied some changes to ARIA and are monitoring stability, but you can continue to work as normal. We appreciate your understanding.
View All Mass Spectrometry at Instruct
HDX Mass Spectrometry gives information of the exchange of hydrogen for deuterium on the protein backbone. Uptake rate is determined by each site’s solvent accessibility. Comparing the extent of deuterium exchange in a ‘apo’-protein with a target (agonist, antagonist, inhibitor, lipid etc) bound protein can provide information about conformational changes, active sites and important binding residues.
Please get in touch with the administrators for further information on the equipment we have on offer. We try to find tailor made solutions for the users of our setups.
Please contact us before applying for an HDX visit to discuss the appropriateness of the method. Depending on the complexity of your samples, it might be necessary to apply for two visits.
