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Photosynthetic organisms (microalgae and plants) are in constant interaction with their environment, responding to various abiotic pressures (temperature, nutrients, light), as well as biotic ones (symbiosis, parasitism). Molecular approaches (‘omics’) have improved our understanding of the adaptive mechanisms to these changes. However, the cellular architecture and structural organisation of organelles such as the chloroplast and mitochondria must be revealed to fully understand how organisms respond to their environment.
3D electron microscopy has become one of the essential approaches for revealing and deciphering the mechanisms of cellular plasticity. Technological advances and cryogenic sample preparation now make it possible to visualise cellular structures, membrane arrangements, contacts between organelles, and macro-complex structures in their cellular context (in situ structural biology). The laboratory Cell and Plant Physiology (LPCV), which aims to understand the adaptive response of microalgae and plants at multiple scales, has been applying 3D electron microscopy (FIB-SEM) in this field, thanks to the technological environment of IRIG and its collaboration with IBS. This work has led to several publications describing the morphological changes in microalgae in different abiotic and biotic conditions (Uwizeye et al. 2021, PNAS, PMID:34215695; Uwizeye et al. 2020, Nat. Commun, PMID:33594064; Decelle et al. 2022 ISME journal PMID:35804051; Ezzedine et al. Nat Commun).
To further understand subcellular plasticity in microalgae at high resolution (< 1 nm) and visualise native structures (organelles such as chloroplast and protein complexes) in their cellular environment, cryo-electron tomography (cryo-ET) is becoming a pivotal imaging approach. Therefore, CEA Irig is recruiting a researcher to develop and apply cryo-ET on microalgae from laboratory cultures and field samples. At LPCV, you will contribute to the research themes of the Photosymbiosis team led by Johan Decelle (https://photosymbiosis.com/), to apply cryo-ET on symbiotic organisms. You will benefit from proximity to the many actors in integrative structural biology in Grenoble, particularly the state-of-the-art infrastructure of the DBSCI (imaging platforms of the LPCV, IBS, PFNC, equipped with instruments such as FIB-SEM and cryo-TEM, etc.). You will work in close collaboration with IBS to build a local network aimed at developing cryo-electron tomography at IRIG. The technological component will be integrated into the laboratory’s expertise in support of in situ monitoring of the physiological responses of microalgae and plants. Solid knowledge in cell and structural biology, as well as expertise in sample preparation and 3D electron microscopy image analysis, are required.
Candidate profile
Why Join Us?
By joining IRIG, you will be part of a dynamic and innovative research environment where you have the opportunity to learn, grow, and play a key role within a centre of excellence.
You will also benefit from:
• A state-of-the-art research ecosystem, covering topics with major societal impact
• Training opportunities to strengthen your skills and boost your career
• A works council (CE) rich in social, cultural, and sports benefits
• Practical daily benefits: staff restaurant, 85% transport subsidy, and much more
• An exceptional living environment in Grenoble, in the heart of the mountains, offering a unique balance between urban life and nature
Would you like to be part of the adventure? Apply now and bring your energy to research and innovation.
In line with CEA’s commitments to promoting the inclusion of people with disabilities, this position is open to all.
How to Apply
To apply, please send the following documents:
For any enquiries about the position and application process, please contact: johan.decelle@univ-grenoble-alpes.fr or laurent.blanchoin@cea.fr
