The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale.
The Mosalaganti lab at the Life Sciences Institute (LSI) is seeking an outstanding postdoctoral research fellow interested in using in situ cryo-electron tomography (cryo-ET) in conjunction with cryo-CLEM to address membrane remodeling events. You will have unencumbered access to our Leica Stellaris cryo-confocal, Aquilos2, Titan Krios G4i (with K3, BioQuantum imaging filter, and phase plate) housed on-site. Candidates should have the following: (1) a strong background in structural biology/biophysics, (2) a sense of independence, and (3) be motivated to push the boundaries of structural biology. You will report directly to Dr. Mosalaganti and perform your work onsite at the LSI.
Responsibilities
Experimental responsibilities will include:
Cryo-CLEM, cryo-FIB, and cryo-ET analyses of cell lines.
Morphometric analysis, subtomogram averaging, and integrative structural and computational analysis.
Serial lift-out from patient tissue samples and organoid models of disease.
Non-Experimental responsibilities will include:
Work with PI to apply for independent research funding.
Work/collaborate with other postdoctoral fellows and graduate students in and outside of the laboratory.
Mentor undergraduates and graduate students in the laboratory.
Assist PI with writing manuscripts and grants.
Required Qualifications
Ph.D. in chemistry, physics, or a related discipline
Minimum of two (2) years of experience in cryo-ET data collection and processing
Ability to work independently and as a team player
Excellent communication skills
Desired Qualifications
Minimum of 2 years of experience in continuous heterogeneity analysis and integrative modeling.
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.
For more information, please contact Dr. Mosalaganti at mosalaga@umich.edu
Application Deadline:
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled any time after the minimum posting period has ended.
