Jobs in Structural Biology and Related Fields

• Perform high throughput crystallization experiments on multiple protein targets with and without ligands.
• Optimize the initial crystallisation hits to obtain stable reproducible crystal systems.
• Implementation of the established techniques of crystal manipulation including ligand soaking, crystal cryo-protection and harvesting.
• Regular use of synchrotron facilities to execute standard x-ray data collection.
• X-ray fragment screening experiments.
• Attention to detail including good record keeping
• To author high quality reports and data summaries.
• To communicate updates to project meetings. 

• Represent Discovery Biology at scientific meetings.
• To work to the highest scientific standards under the direction of the Head of Crystallography.

Job Requirements

• Experience with high throughput crystallisation methods for screening using robotics.
• Know-how of strategy design for crystal conditions optimization.
• Skill in crystal manipulation, including soaking, cryoprotection, crystal harvesting.
• Experience in synchrotron source X-ray diffraction experiments, data collection optimization and beamtime preparation.
• Proficiency with X-ray data processing, structure solution and refinement.
• Knowledge of ligand chemical restraints definition and ligand structure refinement.
• Excellent interpersonal intelligence
• A demonstrable analytical approach to problem solving
• The ability to work as part of a team.

Desirable:

• Understanding of all crystallographic methods (e.g. microbatch)
• Comprehension of others structural biology techniques (e.g. SAXS and Electron Microscopy).
• Experience in designing constructs for recombinant protein production of crystallographic targets.
• Previous work experience in an industrial environment.

For more information and to apply please follow this link