Integrative Modelling Services

The following online services are available for building models with combined techniques:

• HADDOCK2.2 (Utrecht University)

   Information driven biomolecular docking based on the HADDOCK software as described in http://www.bonvinlab.org/software/haddock2.2/haddock.html Several access levels to the portal are provided exposing an increasing number of options / parameters:
  • HADDOCK server: the Easy interface
  • HADDOCK server: the Prediction interface
  • HADDOCK server: the Expert interface (requires Expert level access)
  • HADDOCK server: the Refinement interface (requires Expert level access)
  • HADDOCK server: the Guru interface (requires Guru level access)
  • HADDOCK server: the Multi-body interface (requires Guru level access)
  • HADDOCK server: the File upload interface
  • HADDOCK server tool: generate AIR files for multibody docking

• DISVIS (Utrecht University)

  DisVis allows you to visualize and quantify the information content of distance restraints between macromolecular complexes

• POWERFIT (Utrecht University)

  PowerFit automatically fits high-resolution atomic structures into cryo-EM densities

• SPOTON (Utrecht University)

  SpotOn is a robust algorithm developed to identify and classify the interfacial residues as Hot-Spots (HS) and Null-Spots (NS) with a final accuracy of 0.95 and a sensitivity of 0.95 on an independent test set.

• DIPCHECK (EMBL)

  DipCheck
  is a validation tool for the evaluation of protein backbone geometry, developed by Joana Pereira and Victor Lamzin at the EMBL Hamburg. The tool uses a Euclidian 3D space (DipSpace) of the orthogonal descriptors of the geometry of a 5-atom dipeptide unit: CAi-1-Oi-1-CAi-Oi-CAi+1. The DipSpace database contains 1,024,000 data points derived from well-refined structures deposited in the PDB.