Two Higher Scientific Officer positions in recombinant protein purification are available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CCDD (refer to the links below). The team uses biochemical and biophysical assays to perform small-molecule high-throughput screening and fragment-based hit discovery, coupled with X-ray crystallography to enable structure-based drug design. These methodologies are underpinned by state-of-the art protein expression, purification and biophysical characterisation capabilities, allowing for the generation of large quantities of high-quality protein targets. We are seeking highly motivated scientists to join the team, with expertise in protein expression, protein purification and biophysics. The successful candidates will be carrying out protein expression and purification as part of the CCDD’s research programmes and will be responsible for establishing biophysical assays such as Surface Plasmon Resonance (SPR), Thermal Shift Assay (TSA) and ligand-observed NMR (LO-NMR) to characterise these protein targets and their protein-protein and protein-ligand interactions. The HSOs will be integral members of multidisciplinary project teams within the CCDD at the ICR Sutton site, and will interact closely with biologists, computational chemists, medicinal chemists, assay scientists and structural biologists.
Higher Scientific Officer – Protein production, purification and biophysics
Higher Scientific Officer – Protein production and purification
The posts are offered on a fixed term contract of 2 years.
