Jobs in Structural Biology and Related Fields


Senior Scientist (Protein Engineer) position at ModeX Therapeutics (Weston, MA, USA)


Massachusetts, United States
Application deadline: 30 Nov 2023


ModeX is a clinical-stage biopharmaceutical company developing next-generation multispecific antibodies and vaccines for cancer and infectious disease. ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex disease than traditional approaches. Our pipeline includes candidates against both solid and hematological tumors as well as several of the world's most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients.

To apply for this position please follow the link to the website but also please send a copy of your CV to Yuri Lozzo Yuri.Iozzo@ModeXTX.com

Job Summary

ModeX is looking for an experienced protein engineer with strong background in structural biology, protein generation, liability mitigation and design. This role mainly focuses on facilitating multiple projects through early engineering interventions during the candidate selection and development. Occasional outsourcing of X-ray and cryo-EM structure solving efforts is expected as well as managing connections with several CROs.

Key accountability and responsibilities include:

  • Project analysis and making pro-active engineering initiatives,
  • Rational engineering and software-assisted engineering,
  • Antibody design including format selection, linkers, mutations, liability removal,
  • Structure generation with AF2 and structure analysis,
  • Managing structural biology CROs,
  • Structure solving through outsourcing and analysis of results,
  • Molecular dynamics and analysis of results,
  • Supporting multiple projects at a time.

Key qualifications:

  • M.Sc. or Ph.D. in chemistry, biology, or other relevant discipline,
  • Minimum 2 years of prior industry experience (the hiring manager will consider postdoc years in lieu of industry experience),
  • Strong hands-on protein design and engineering skills,
  • Experience with protein production and purification,
  • Solid background in structural biology with a publication record,
  • Proficiency with protein design, engineering, and structural biology software (PyMol, Chimera, Coot, Schrodinger etc),
  • Excellent presentation skills.­

Massachusetts, United States

Senior Scientist (Protein Engineer) position at ModeX Therapeutics (Weston, MA, USA)