We’re looking for an enthusiastic structural biologist with experience in protein biochemistry, crystallography and cryo-electron microscopy to join our Structural Biology and Protein Sciences group at Pfizer La Jolla. For further information and to submit your application please follow the link here.
Why Patients Need You
Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.
What You Will Achieve
Pfizer Worldwide Research and Development, La Jolla, CA, has an open position at the Senior Scientist level for a highly motivated and talented research scientist in the Structural Biology and Protein Sciences (SBPS) Group within the Department of Oncology Medicinal Chemistry. The SBPS mission is focused on enabling oncology drug discovery programs with protein tools, structure, function, and dynamic information. The position will primarily support the antibody-drug conjugate (ADC) portfolio with opportunity to also contribute broadly to small molecule focused programs.
How You Will Achieve It
As part of a gene-to-structure team within SBPS, the successful candidate will carry out, as needed, a full range of gene-to-structure and protein sciences experiments (including construct design, protein engineering, expression, purification, biophysical characterisation, and structure determination by crystallography and cryo-electron microscopy) to advance multiple ADC drug discovery projects and science objectives in parallel.
The successful candidate will collaborate and interact with colleagues across the SBPS group and Medicinal Chemistry and Computational Chemistry groups in Bothell, WA, and La Jolla, CA, and will be an SBPS discipline resource in multi-disciplinary drug discovery team settings, contributing to robust and timely team problem solving and decision making. Occasional travel to Pfizer Bothell, WA is required.
Qualifications (Must-Have)
• Ph.D. (or equivalent) in biochemistry, structural biology, or a related field.
• Extensive experience in protein biochemistry focused on exceptionally challenging biological systems, including construct design, expression (in multiple expression systems), protein purification, and biophysical characterisations.
• Extensive experience in all aspects of single particle cryo-electron microscopy, including grid preparation, data collection and data processing with proficiency in state-of-the-art software packages for cryo-electron microscopy, molecular modelling, and analysis.
• Hands-on experience in structure determination by X-ray crystallography, including crystallisation/small molecule co-crystallisation, model building, and refinement.
• Demonstrated scientific leadership to independently design, implement, and drive successful outcomes in gene-to-structure experimental strategies and experiments.
• Outstanding publication record reflecting scientific drive, productivity, and creativity across all disciplines of modern structural biology and protein sciences.
• Must be able to thrive and deliver results on goals in a fast paced, dynamic, and highly multi-tasking environment.
• Must be self-motivated and work well independently in an inclusive manner.
• Excellent communication and presentation skills that positively contribute to an environment where high value is placed on enabling and engaging teammates in robust science, scientific dialog, partnership, and teamwork.
Nice-to-Have
• Postdoctoral and/or industry experience
• Expertise in ADC technologies, including tumor associated antigen biology and internalisation mechanisms.
• Experience in the use of ML/AI based approaches for structural biology, including protein engineering, construct design, and cryo-electron microscopy data processing.
• Experience in sample preparation, data collection, and processing of cryo-electron microscopy for helical samples or cryo-electron tomography.
• Broad understanding of biochemical assays, chemical biology, mechanistic enzymology, pharmacology.
Deadline: 4 September 2024
