Research Scientist position at Vertex pharmacuticals
Vertex Pharmaceuticals, Oxford, United Kingdom
Application deadline: 01 Jun 2021
Vertex are currently seeking an innovative and enthusiastic Research Scientist to join the Protein, Cell and Structural Sciences group at our Oxford site. The Protein Biochemistry & Biophysics Research Scientist II will design and execute experiments for protein expression and purification for disease-relevant targets for major research projects. The major responsibilities of this role will include small- and large-scale protein expression and purification, biophysics including Surface Plasmon Resonance and Microscale Thermophoresis. You will also be responsible for communicating with CROs and keeping a track of their output.
The successful candidate will have an exciting opportunity to contribute to high impact and strategic science across our early research portfolio. As a key player within multi-disciplinary drug discovery teams, you will be exposed to every aspect of drug discovery and development in one of the world's leading biotechnology companies with an uncompromising commitment to patients.
Key Duties and Responsibilities:
- Expression and purification of proteins for biophysics, structure determination and high throughput assays
- Maintain a deep and broad knowledge of relevant scientific literature
- Display great ability to productively disseminate ideas across discipline- and Project-boundaries
- Communicate effectively in verbal presentations and in writing technical reports
- Demonstrate ability to solve complex problems to attain crucial Project goals
Education and Experience:
- Ph.D. (or equivalent degree) in biological science and preferably relevant post-doctoral experience.
- Practical experience of recombinant protein expression in several mature platforms including mammalian (stable and transients), insect cells and E.coli is essential. Strong practical experience in protein purification including IMAC, IEC, SEC, IEX, HIC, fusion protein cleavage technologies, use of AKTA system-based chromatography.
- Familiarity with high-throughput methods for assessing protein expression and purification yields and quality.
- A track record in delivering high impact results in protein science within academic or pharmaceutical industry settings as demonstrated through a strong publication history, supported by evidence of individual contributions to projects.
- Experience in the use of a range of biophysical methods, particularly in the context of assessing small molecule target engagement would be an advantage.
- Strong understanding of molecular biology, protein engineering, assay development, and/or high-throughput screening workflows would be an advantage.
- Strong interpersonal and troubleshooting skills.
- Demonstrate excellent record keeping, communication and presentation skills.
For more information and to apply please follow this link
