Jobs in Structural Biology and Related Fields

Job Role: Biology – Expression & purification of membrane and soluble proteins

Job Hours: Full-Time contract position (1 year)

Sector: Private

Location: Slough, Thames Valley, UK

Company: UCB 

Salary: Competitive package with benefits

 

UCB aspires to be the patient-centric global biopharmaceutical leader transforming the lives of people living with severe diseases. We focus on central nervous system and immunology disorders and our promise is to help tackle the serious unmet medical needs affecting patients around the globe. Our ambition is to offer them innovative medicines and ground-breaking solutions that go beyond the drug. An important part of our philosophy is to take a holistic approach to patients, which aims to find solutions tailored to their circumstances. By considering patients’ individual characteristics and lifestyles, such as age, diet, family history and genetic profile, we are also coming closer to providing personalised therapies.

We are committed to enabling cutting-edge scientific research that is driven by the patients' needs.

 

UCB New Medicines is our discovery research to clinical proof-of-concept organisation responsible for developing a rich pipeline of differentiated molecules by channeling best in class science for industry-beating performance. Our world class research centres are home to a wealth of internal skills and experience in our chosen therapeutic areas, allied to unique and proprietary technology platforms. Our established and highly effective networks with the leading academic establishments and industrial partners enable access to novel technologies, targets and collaborative research.

 

We are currently seeking an experienced protein biochemist with expertise in the expression and purification of a variety of recombinant proteins including integral membrane proteins for use in structural studies to join our Protein Expression & Purification Department. The successful candidate will have the opportunity to make a significant scientific contribution to exciting drug discovery projects. As well as a track record of working with multi-pass membrane proteins, the individual should have an excellent understanding of their structure and function.

 

 

• Take a lead role in the expression and purification of recombinant proteins including multi-pass membrane proteins for structural studies.

• A key aspect of this position will be communication both within the protein group and across multiple disciplines (project teams, enzymologists, crystallographers and CADD groups) ensuring that information on work progress is relayed in a clear manner, highlighting any technical issues and providing potential solutions.

• Keep abreast of and implement technology developments within the area of protein expression and purification especially techniques involved in the production of recombinant proteins including multi-pass membrane proteins.

  

 

Preference will be given to candidates who have spent time working within labs recognised for their expertise in the field of multi-pass membrane proteins. 

We are looking for candidates who can demonstrate the following skill sets: 

 

• Familiar with insect and mammalian cell expression systems.

• Fully independent in purification techniques (affinity chromatography, ion exchange, SEC and HIC).

• Extensive working knowledge of AKTA purification platforms and associated software.

• Comprehensive knowledge and experience with software used in manipulating protein and DNA sequences and molecular visualisation of proteins (PyMOL or similar). 

• An excellent knowledge of the literature around the generation of recombinant proteins including multi-pass membrane proteins for structural studies.

 

In addition, all applicants must possess excellent written and verbal communication skills.

 

 

If you currently have the right to work in the UK and wish to apply, send your CV to protein.purification@ucb.com