Are you an ambitious researcher looking for your next challenge? Do you have an established background in Cell Signaling Structural Biology and cryoEM? Do you want to further your career in one of the UKs leading research intensive Universities?
We seek to appoint two Postdoctoral Research Fellows to the research team led by Dr Elton Zeqiraj at the Astbury Centre for Structural Biology, University of Leeds, Leeds, UK. The positions are collaborative projects jointly funded by University of Leeds and Novo Nordisk Foundation Center for Basic Metabolic Research at University of Copenhagen and are available for 2 years with optional extensions subject to funding approval. The research topic will build on previous successful collaborative work from Zeqiraj (Leeds) and Sakamoto (Copenhagen) groups (Zeqiraj et al., 2014, PNAS; Hunter et al., 2018, Nature Medicine, Walden et al., 2019, Nature).
You will undertake biochemical, structural and functional studies of macromolecular complexes involved in cell signalling regulation. The position will suit someone interested in cryo-electron microscopy, cell signalling biology and drug discovery.
You should have or be very close to completing a PhD in Structural Biology or related discipline, with experience in cryo-electron microscopy, X-ray crystallography and/or protein production of multimeric complexes.
The Astbury Centre for Structural & Molecular Biology at the University of Leeds has excellent facilities for cryo-electron microscopy (two Titian Krios 300 kV equipped with Falcon-4 detectors, protein crystallography (crystallisation robots, automatic imaging), and protein production with expertise in multi-subunit expression in insect cell, yeast and bacterial expression systems. The Astbury Centre is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, mass photometry, fluorescence, multi-angle light scattering). Additionally, the University provides a state-of-the-art infrastructure for mammalian cell culture, high-throughput screening, imaging, mammalian genetics, chemical biology and proteomics.
To explore the post further or for any queries you may have, please contact:
Dr Elton Zeqiraj, Sir Henry Dale Fellow,
Email: E.Zeqiraj@leeds.ac.uk
