CHNUK: Structural approaches to novel fragment based and natural product antibiotic discovery
Applications are invited for a highly motivated and experienced postdoctoral researcher to join an active research group at the School of Life Sciences, University of Warwick supervised by a team headed by Prof Chris Dowson with Prof Frank vonDelft at Oxford University and Diamond Light Source. The project, which has been recently supported by the Newton Fund, focuses on acquiring specific structural and biochemical data using a novel strategy of HT affinity crystallography, using robust crystals of well validated and novel antibacterial targets to identify either fragment-based inhibitors or inhibitors identified by crystallography directly from complex mixtures of natural products. This position is available for up to 18 months in the first instance and will involve substantive interactions with academic colleagues at Harwell and those in China.
You will have a PhD in a relevant field. The successful applicant should have proficiency in molecular cloning, protein expression, purification, crystallization, X-ray crystal structure determination in particular and should have a background in biochemistry or molecular biology/ drug discovery generally.
The School of Life Sciences at Warwick is equipped with state-of-the-art protein expression and purification apparatus, including high-throughput facilities for crystallisation and visualisation as well as regular synchrotron access in the UK and abroad. The wider laboratory is very well equipped with microbiological, biochemical and biophysical infrastructure and the successful applicant will join a wider team of highly motivated scientists working on a range of antimicrobial discovery and resistance projects.
Find out more and apply here.
