Jobs in Structural Biology and Related Fields

Protein crystallographer position available at Sprint Bioscience (Huddinge, Sweden)

Huddinge, Sweden

Application deadline: 01 Dec 2021

Sprint Bioscience are looking for a protein scientist with a passion for protein X-ray crystallography. Apply today if you thrive in an efficient and multi-disciplinary research environment focused on driving innovative drug programs forward. We give you the opportunity to develop both within and outside of your discipline.

SPRINT BIOSCIENCE IN SHORT

Sprint Bioscience develops small-molecule drugs to fight cancer. With fragment-based drug design methods, advanced technical approaches, and leading specialists, we develop the drugs of the future - from the idea stage to a clinical candidate with the goal set at being "First-in-Class". Our business model is to identify and run drug development projects and license these in the preclinical phase to the global pharmaceutical industry. We choose projects with the greatest technical and commercial potential for success. Sprint Bioscience has had a yearly growth since our start in 2009. Today, we are about 30 committed employees who work closely together in a stimulating environment with cutting-edge methodology and challenging projects. We also collaborate with several academic and industrial partners from all over the world. We are situated in tailored designed premises in Flemingsberg - Huddinge, 20 minutes by train from Stockholm City.

ABOUT THE POSITION

You will be a member of the Structural Biology team, consisting of scientists with expertise in the different areas related to protein crystallography (recombinant protein expression and purification, crystallogenesis, structure determination). Your main goal will be to develop crystal systems which will allow the generation of high-resolution crystal structures of complexes between proteins from our portfolio and the compounds synthesized by our Medicinal Chemistry team. Because Sprint Bioscience favored hit-to-lead approach is Structure-Based Drug Design, this activity is essential in order to progress our molecules towards a drug-candidate. Depending on your competences, you could also take part in the further structure determination, model refinement and structural analysis steps. We work in efficient and dynamic project teams, which are adaptable and change depending on project priorities. This is a full-time permanent position.

YOU WILL MAKE A DIFFERENCE

You will bring your expertise into a team of dedicated scientists. You need collaborative skills and to communicate well when supporting parallel projects in a multi-disciplinary environment. Our company language is English.

Your main contributions in the field of Structural Biology will be:

• Developing stable crystallization protocols suitable for the study by X-ray crystallography of protein-ligand complexes
• Applying these protocols to deliver high-resolution diffraction data to support the chemistry programs. Optional: delivering 3D model to chemists and guiding them in their analysis
• Sharing responsibilities in term of organization of the structural biology activities (organization of synchrotron sessions, maintenance of the equipment)
• Implementing new workflows and new methods for protein crystallography and structural biology in general

To be successful in this position you will need:

• An extensive experience and expertise in crystallization of soluble proteins and particularly of protein-ligand complexes
• A passion for structural biology (protein crystallography) and particularly method development in the different fields of the discipline

Having knowledge and experience in the following fields will be considered as benefits:

• Structure-based drug-design softwares
• Fragment-screening by X-ray crystallography
• Structure determination (from data collection to model refinement and analysis)
• Protein purification and characterization
• Methods in Structural Biology other than X-ray crystallography

You will be able to apply to the position by following the link