Applications are invited for a Postdoctoral Research Associate position, funded by the Royal Society, for up to 30 months to work with Dr Jon Agirre in the Department of Chemistry. The successful applicant will join a vibrant team of researchers at the heart of the world-leading York Structural Biology Laboratory (YSBL). The work of the laboratory over the years has included the delivery of world-leading methods and experimental discoveries, training and nurturing hundreds of outstanding scientists in the process.
In collaboration with Dr. Elisa Fadda (Maynooth University, Ireland), the team have developed proof-of-concept software that models protein glycosylation into AlphaFold models. This task has been automated and integrated into the new Python interface of the carbohydrate-specific Privateer software. In parallel, they have developed infrastructure and analyses that allow them to get a clear picture of glycans and their interactions. They expect that this technology will enable the successful applicant to, based on existing glycobiological knowledge, extend the Privateer software to predict, build and adapt models of glycans onto AlphaFold models.
Main duties and responsibilities:
- To develop and extend the Privateer software to predict, build and adapt models of glycans onto AlphaFold models.
- To further existing collaborations with CCP4, CCP-EM, PDB-REDO, the Protein Data Bank and the AlphaFold Protein Structure Database.
For informal enquiries: please contact Dr Jon Agirre, jon.agirre@york.ac.uk
