The lab is interested in understanding molecular mechanisms and physiological functions of membrane transport proteins that play important roles in human health and disease (for most recent examples: Nature Structural & Molecular Biology 2018, doi: 10.1038/s41594-018-0037-5; Nature Microbiology 2018, doi: 10.1038/s41564-018-0255-y). We use a combination of approaches including X-ray crystallography, single-particle cryo-electron microscopy (cryoEM), biochemical reconstitution and electrophysiology. The lab is well equipped with state-of-the-art setup for membrane protein biochemistry, biophysics and structural biology. In addition, we have excellent access to synchrotron X-ray facilities including the Advanced Photon Source and state-of-the-art Titan Krios G3 cryo-electron microscope at the Washington University Center for Cellular Imaging. \
Successful candidates are expected to be highly motivated and well trained in membrane protein biochemistry, or in structural biology using X-ray crystallography or cryoEM. Please send your application including cover letter, research interest, CV, and contact information for three references to yuanp@wustl.edu.
