Jobs in Structural Biology and Related Fields

Postdoctoral position in Structural Biology of Ion Channels

University of Illinois Urbana-Champaign, Illinois, United States

Application deadline: 08 Nov 2021

The Grosman lab at the University of Illinois at Urbana-Champaign is seeking to fill an NIH-funded postdoctoral position to work on the structural aspects of pentameric ligand-gated ion channels. The laboratory combines high-resolution electrophysiology, molecular simulations, and structural biology to address fundamental questions about ion-channel mechanisms. Previous experience with the purification of eukaryotic membrane proteins and structure determination using single-particle cryo-EM is absolutely required. Salary will follow NIH guidelines. 

Interested individuals should contact Prof. Claudio Grosman (grosman@illinois.edu) with a CV, a 1–2 page description of previous research, and names and contact information of 2–3 references. Students in their final year of Ph.D. training are also welcome to apply. 

Recent select publications from the Grosman lab are listed below. A complete list of publications from the Grosman lab can be found on Prof. Claudio Grosman’s NCBI bibliography page. 

Recent Select Publications 

• Kumar P, Cymes GD, Grosman C. Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel. Proc. Natl. Acad. Sci. USA. 2021;118(23). 

doi: 10.1073/pnas.2100164118 

• Cymes GD, Grosman C. Signal transduction through Cys-loop receptors is mediated by the nonspecific bumping of closely apposed domains. Proc. Natl. Acad. Sci. USA. 2021;118(14). doi: 10.1073/pnas.2021016118 
• Sethuramanujam S, Matsumoto A, deRosenroll G, Murphy-Baum B, Grosman C, McIntosh JM, Jing M, Li Y, Berson D, Yonehara K, Awatramani GB. Rapid multi-directed cholinergic transmission in the central nervous system. Nat. Commun. 2021;12(1):1374. 

doi: 10.1038/s41467-021-21680-9 

• Kumar P, Wang Y, Zhang Z, Zhao Z, Cymes GD, Tajkhorshid E, Grosman C. Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer. Proc. Natl. Acad. Sci. USA. 2020;117(3):1788-1798. 

doi: 10.1073/pnas.1906823117