Applications are invited for a postdoctoral researcher position in the laboratory of Dr Paul Miller at the Department of Pharmacology, University of Cambridge, beginning from January – April 2023.
The project will study small molecule and/or antibody modulators of ion channels as research tools and therapeutic leads, in order to study channel subtype contributions to CNS physiology and disease and empower drug discovery. This is a great opportunity to gain experience in one or more aspects of handling challenging membrane proteins, understanding small molecule and/or antibody modulation, and cryo-EM, ideal for follow-on academic and biotechnology careers. The lab utilises mammalian cell protein expression systems, membrane protein purification, and cryo-EM via Arctica and Krios microscopes with K2/K3 direct detectors, and also has manual and automated electrophysiology equipment.
The applicant will be about to obtain a PhD or have obtained a PhD within the last 5 years. Experience in molecular biology, protein production, purification and structural biology (X-ray crystallography or cryo-EM) is required. You must be a careful and methodical worker, paying attention to accuracy, be able to take responsibility and interact as part of a tightly knit team, and be willing to work in a collaborative environment. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction.
A recent relevant publication from the lab is:
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS.
Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABA-A receptors.
Nature. 2022 Feb;602(7897):529-533. PMID: 35140402
Informal enquiries about the position can be made to Dr Paul Miller (pm676@cam.ac.uk)
For enquiries about the online application process please contact Debbie Stanley, phar-hr@lists.cam.ac.uk
