Jobs in Structural Biology and Related Fields

PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

University of Southern California, california, United States

Application deadline: 30 Nov 2023

The position is available starting immediately in the Department of Biological Sciences at the University of Southern California and is initially limited to 2 years, with possible extension.

The research focuses on the structural biology of G protein-coupled receptors involved in neurobiology and immunology, using single particle cryoEM, complemented with biophysical assays. 

USC has a suite of research facilities and has recently commissioned a brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS and screening
•  Core facility for insect- and mammalian cell expression
•  High performance computing for data processing/analysis

Qualified candidates must have a Ph.D. degree with a solid background in structural biology and biophysics/biochemistry. Previous work with membrane protein purification and experience with cryoEM data analysis is a plus. A successful candidate is expected to be highly skilled and self-motivated and is willing to work in a collaborative environment. The Postdoctoral salary depends on qualifications and relevant experiences according to USC standards.

Interested candidates should apply directly with Cornelius Gati at gati[at]usc.edu. Please attach a cover letter, Curriculum Vitae, research statement, publication list and a reference letter. There is no deadline for this posting and applications will be evaluated on a rolling basis.

Recent work from our group includes:

Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)

Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. Nature. 606 (2022) 820-826

Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C*, Cherezov V*. Nature. 584 (2020) 298-303

A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412