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Molecular basis of Multidrug Transport in Staphylococcus aureus
Start date: Immediately
The project: Antibiotic resistant bacteria is becoming one of the leading threats to human health on a global scale. One of the most concerning bacteria is gram-positive Staphylococcus aureus, due to the existence of various resistant strains, killing thousands every year. Multidrug efflux pumps are key players in the development of resistance as they provide the required first-defense mechanism upon cytotoxic attack, allowing for subsequent genetic adaptation. This project aims at providing a thorough molecular understanding of multidrug export in S. aureus, by combining high resolution information and detailed description of the molecular motions. This will be achieved through a multidisciplinary approach encompassing X-Ray Crystallography, Single Molecule FRET, EPR spectroscopy and functional characterization.
Host laboratory: The Structure and Function of Membrane Biology Laboratory (SFMB) is focused on understanding how membrane proteins work, using a combination of structural and functional approaches. The SFMB is affiliated with the Université Libre de Bruxelles and is located in Brussels, Belgium, the capital of Europe.
Profile: Candidates should hold a recent PhD and have a background in biochemistry and/or, molecular biology. Experience in protein expression and purification is required, preferably with membrane proteins. Experience in biophysical methods and/or crystallography is a strong plus. The successful candidate must be creative, motivated and enjoy both working independently and in a collaborative setting. Candidates should not be Belgian nationals.
Applications: Send a CV, a list of publications, a short overview of research activities and the name of two to three references to Cedric.Govaerts@ulb.ac.be. Preselected applicants will be requested to travel to Brussels for a lecture and an interview.
