The Pancera lab, within Fred Hutch’s Vaccine and Infectious Disease Division, works towards the development of safe and effective vaccines against HIV-1, malaria and other pathogens. The group focuses on structural characterization of these immunogens and their immune responses. The laboratory utilizes a wide range of in vitro and in vivo systems and cutting-edge technologies and techniques. Experimental approaches include high-throughput crystallography, nsEM, cryoEM, bioinformatics, and computational approaches, specialized immunological methodologies and assays, and molecular and cellular biology techniques. Our major emphasis is the design of protein immunogens and understanding the immune response following vaccination or natural infection.
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