Jobs in Structural Biology and Related Fields

Postdoc position in structural biology of rNA modification, Uppsala University, Sweden

Uppsala University, Uppsala University, Sweden

Application deadline: 16 Feb 2023

The group of Prof. Maria Selmer at Uppsala University is looking for a highly motivated postdoc who will work on structural and mechanistic aspects of how rRNA methyltransferases contribute to ribosome biogenesis and antibiotic resistance. This will involve a combination of structural and biophysical techniques, with a focus on single-particle cryo-EM.The person will work within a VR-funded project aiming to clarify structural and mechanistic aspects of how rRNA methyltransferases contribute to ribosome biogenesis and antibiotic resistance through specific recognition of transiently available substrates. This will involve ribosome purification, expression and purification of proteins, characterization with biochemical and biophysical methods, structural studies with primarily single-particle cryo-EM, and possibly single-molecule in vivo tracking.The researcher will work in close collaboration with PhD students and postdocs with partly complementary competences, but is expected to run his or her project independently. The project will involve collaboration with the Johansson lab (https://www.icm.uu.se/molecular-systems-biology/johansson-lab/). Strong merits with documented lab skills, motivation and good collaboration skills are required.

Requirements

PhD degree in structural biology, biochemistry or biophysics or a related area, alternatively a foreign degree equivalent to a PhD degree in these topics. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.

• Documented experience of work with ribosomes and/or RNA, involving purification and functional or structural characterization
• Documented experience of structural biology and/or biophysical methods. Experience in or interest to learn single-particle cryo-EM
• Demonstrated scientific excellence; evidenced by publication track record as well as track record of presenting at national and international meetings
• Excellent oral and written communication skills in English
• Good collaboration skills

The application should include:

• Cover letter (maximum 1 page)
• Degree certificate
• CV including publication list
• Contact information for three reference persons

The position is a 2-year postdoc employment with possibility of extension, funded by the Swedish Research Council.

Application deadline February 16.