Jobs in Structural Biology and Related Fields

A postdoctoral position is available immediately to work on ion channel structural biology in the lab of Filip Van Petegem, Department of Biochemistry and Molecular Biology.

 The project combines X-ray crystallography, cryo-EM, and electrophysiology. Our lab has steady access to the in-house X-ray and cryo-EM facilities: 

• Microscopes: 300kV Titan Krios with Falcon IV detector and Selectris Energy filter.   A 200kV Glacios (Falcon III detector) is available for prescreening grids.
• X-ray equipment in the lab includes Mosquito and Dragonfly robotics, and we have regular access to an in-house X-ray diffractor (Rigaku Micromax-007 HF with Saturn 744+ CCD detector) and various synchrotron beamlines

Minimum requirement for applicants include a PhD in Biochemistry or a related discipline with extensive experience in either X-ray crystallography or cryo-EM, as well as protein expression and purification.  Direct experience with membrane proteins is an additional plus.

 The lab values diversity and inclusivity, and applicants from all backgrounds are encouraged to apply. This is an opportunity for people with structural biology expertise to learn electrophysiological methods.

 Recent work from the lab includes an investigation of how Ryanodine Receptors are modulated by small molecules, disease mutations, and post-translational modification, using cryo-EM, X-ray crystallography, planar lipid bilayer electrophysiology, and enzyme kinetics.

Woll et al (2021) Nature Comm. 12:807

Ma et al (2020) Nat Chem Biol. 16,1246-1254

Haji-Ghassemi et al (2019) Molecular Cell 75,1-14

For more information on recent work, see http://crg.ubc.ca/VanPetegem/

The lab is housed within the Life Sciences Centre at UBC (lsi.ubc.ca), located on the Point Grey campus in Vancouver.

Interested candidates should send a CV, along with names and contact details for 3 references to filip.vanpetegem@gmail.com.