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A postdoctoral training position is available in the laboratory of Dr. Michael Rosen, in the Department of Biophysics and Howard Hughes Medical Institute at UT Southwestern Medical Center. We seek to recruit individuals who can apply cryoelectron tomography to understand the molecular organization of biomolecular condensates in vitro and in cells.
Following on our studies of biochemically reconstituted chromatin condensates (Gibson et al., Cell, 2019; Gibson et al., PNAS, 2023), we have developed methods to determine the higher-order organization of polynucleosome arrays in high-pressure frozen, cryoFIB milled samples using cryoET. We now plan to expand this technology to further explore chromatin itself, as well as the structures of various chromatin machines working within condensates. Additionally, we will apply the tools and knowledge to other biomolecular condensates. We will examine both biochemically reconstituted condensates as well as their cellular counterparts, with a goal of relating structural organization to function across a range of length scales (Lyon et al., Nature Reviews Molec Cell Biol, 2021).
Members of the Rosen lab have access to outstanding cryoEM facilities at UTSW, including two Titan Krios microscopes, an Aquilos 2 cryoFIB mill, a Stellaris-5 cryo-confocal light microscope and a Leica EM Ice high pressure freezer; as well as cryoEM instrumentation at the Janelia campus of the Howard Hughes Medical Institute. Members also benefit from a deep understanding of condensate biophysics, biochemistry and biology within a leading lab in the field.
Candidates must hold a recent Ph.D. and have prior experience in cryoelectron microscopy, ideally in cryoelectron tomography and complementary cryoFIB milling.
Candidates should send C.V. and a 1-page statement of research experience and future goals to michael.rosen@utsouthwestern.edu and arrange to have three letters of reference sent to this same address.
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.
