University of Dundee are seeking a highly motivated structural cell biologist / biophysicist (position SLSC0161) and a research technician (position SLSC0162) to join the laboratory of Dr Alessio Ciulli to work on an exciting drug discovery project funded by an industrial partner. The Ciulli lab is broadly interested in elucidating and characterising Protein-Protein Interactions (PPIs) important to human biology and relevant to human diseases, and targeting them using drug-like small molecules.
The project aims to develop novel small-molecule ligands and chemical probes targeting Cullin RING E3 Ubiquitin Ligases (CRLs) - the largest family of multisubunit ubiquitylating enzymes – using structure-based drug design. CRL-targeting probes can be used in their own right as E3 ligase modulators of the biological pathway in which the specific CRL is involved. In addition, CRL-targeting ligands can be suitably tethered with another ligand for a target protein of interest, yielding bifunctional compounds that hijack CRL activity and the ubiquitin proteasome system to induce targeted protein degradation.
These are unique opportunities to gain experience in industry-style early-stage drug discovery within an academic setting.
For further information on the positions and to apply on-line, please click here
The following vacancy is also available on this project: SLSC0160: Postdoctoral Research Scientist (Medicinal Chemistry / Chemical Biology / Organic Chemistry)
Closing Date: 31 October 2016
For informal enquiries please contact me directly by E-mail: a.ciulli@dundee.ac.uk<mailto:a.ciulli@dundee.ac.uk>
