The Associate Laboratory REQUIMTE-CQFB, from Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (https://www.fct.unl.pt/en) is opening a post-doc position to integrate a multidisciplinary team in Structural Biology. The applicant must have a PhD in biochemistry, biology or related fields and preference will be given to demonstrated experience in protein crystallography and small molecules crystallography.
Contract: Initial duration is 3 months, renewable for additional 12 months, with starting date predicted for 1st of September of 2013.
Monthly Stipend: According to the amounts stipulated
by FCT (www.fct.pt) for Research Grants in Portugal - 1495,00€
Job description: The main purpose of the work is to structurally characterize at the molecular level the interaction of plasma proteins (human serum albumin and human transferrin) with potential drugs (CORMs).
These are CO releasing molecules that have demonstrated therapeutic effects in several models of disease (inflammation, apoptosis, cell proliferation, among others) (Santos-Silva, JACS 2011, Curr Med Chem 2011; Santos, J Inorg Biochem 2012; Seixas, Dalton Trans. 2012).
Biochemical and crystallographic studies, in combination with theoretical calculations, will be performed, in the Protein Crystallography lab of the
Chemistry Department from Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa (Lisbon-Caparica, Portugal) under the supervision of Doctor Teresa Santos Silva and Prof. Maria João Romão (http://xtal.dq.fct.unl.pt). The work is part of an on-going collaboration with Prof. Carlos Romão from ITQB-UNL(Oeiras, Portugal), and the Pharmaceutical company Alfama.
Applications should include: motivation letter, Curriculum Vitae, names and emails of 2 possible referees, copy of the degree certificate as well as other documents considered to be relevant, and sent to Dr Teresa Santos-Silva, tsss@fct.unl.pt.
Please go to this website to find about further details on this application and project.
