Job opening for a structural biologist to join the Structural Motility team at the Curie Institute Paris, France.
They are looking for a post-doctoral fellow to join the team Structural Motility at the Curie Institute (Paris Center) directed by Anne Houdusse.
The Structural Motility team at the Institut Curie has gathered important structural insights on how force generated by molecular motors can power cellular processes in human health and disease. They combine chemical biology and cell biology approaches to test these insights and understand how molecular motors produce force, how their activity is regulated and how they are recruited to their cellular targets. Many of these motors are also involved in human pathologies and they are thus good targets for new therapies which we are helping to develop.
They are looking for an expert in biochemical, crystallogenesis and structural determination studies (X-ray and/or CryoEM). The post-doctoral fellow will also gain expertise in functional and cellular studies.
A solid experience in structural determination is required. Experience in the production and purification of recombinant proteins is a plus but we are ready to train a dynamic and motivated candidate.
If you are interested, please send a CV and a letter of motivation as well as letters of recommendation of your previous employers.
Contact : Anne Houdusse (anne.houdusse@curie.fr)
Recent publications
Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell : 335-346 : DOI: 10.1016/j.cell.2020.08.050
Julien Robert-Paganin, Olena Pylypenko, Carlos Kikuti, H Lee Sweeney, Anne Houdusse Force Generation by Myosin Motors: A Structural Perspective. Chemical reviews : 5-35 : DOI : 10.1021/acs.chemrev.9b00264Robert-Paganin et al, Nat Commun. 10, 3286, 2019.
Robert-Paganin et al, Nat Commun. 9, 4019, 2018.
Planelles-Herrero VJ, Hartman JJ, Robert-Paganin J, Malik FI, Houdusse A. Mechanistic and Structural Basis for Activation of Cardiac Myosin Force Production by Omecamtiv Mecarbil. Nat. Commun. 8, 190, 2017.
Yu I-M*, Planelles-Herrero VJ*, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Myosin 7 and its Adaptors Link Cadherins to Actin. Nat Commun. 8, 15864, 2017.
Houdusse A, Sweeney HL. How myosin generates force on actin filaments. Trends Biochem Sci. 41, 989-97, 2016.
Sweeney HL and Houdusse A, Myosin VI rewrites the rules for myosin motors, Cell, 141, 573-82, 2010.
Sweeney HL and Houdusse A. Structural and Functional Insights into the Myosin Motor Mechanism, Annu Rev Biophys. 39, 539-57, 2010.
