Job opening at ModeX
ModeX Therapeutics, United States
Application deadline: 20 Dec 2022
ModeX Therapeutics is seeking a highly skilled and motivated scientist to support biologics production, characterization, and optimization for developing innovative biotherapeutics. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation biological therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.
ModeX Therapeutics, a subsidiary of OPKO Health, is a biotech based in Massachusetts dedicated to the concept of modulating multiple disease targets with innovative multi-targeting strategies. It was founded by Dr. Elias Zerhouni and Dr. Gary J. Nabel in 2020 with a team of scientists with proven track record from early research to clinical development, regulatory approvals, and commercialization. ModeX is pursuing the development of novel immune-oncology therapeutics for cancers and biotherapeutics against infectious disease.
Major responsibilities
- Interact closely and be part of interdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and the optimization of their biochemical and biophysical properties.
- Contribute to ModeX’s multi-targeting strategy through structure-based antibody design, production, and characterization platforms.
- Develop a high-throughput antibody expression and purification platform and lead the effort in producing high-quality multispecific antibodies for developability assessment and PK/PD studies.
- Perform biochemical and biophysical characterization of diverse biologics molecules, including multi-specifics, fusion proteins, and non-viral particle to support lead candidate selection, focusing on antibody’s biophysical properties including chemical stability, solubility, polyspecificity and polyreactivity.
- Interpret results and present/communicate with cross-functional colleagues for successful execution and completion of projects.
- Stay scientifically current and contribute to the implementation of new technology and instrumentation.
- Ensure effective and timely documentation in electronic laboratory notebooks.
Qualifications
- PhD or MS in biochemistry, structure biology, biomedical engineering, or other life science disciplines
- Minimum of 3 years (PhD)/ 6 years (MS) of relevant experiences
- Knowledge in antibody structure and the development of antibody-based biotherapeutics is preferred.
- Skilled in protein expression in mammalian cells and protein purification using various chromatography methods and instruments such as AKTA FPLC.
- Experience with protein analytic techniques such as HPLC/UPLC, cIEF/CE-SDS, SLS/DLS, and BLI/SPR based protein-protein interaction characterization is a plus.
- Excellent written and oral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solving skills.
- Highly adaptable to a fast-paced work environment and capable to work both independently and collaboratively within project teams.
To apply, please send cover letter and CV to hao.chen@Modextx.com and careers@ModeXTX.com
