Jobs in Structural Biology and Related Fields

Applications Scientist Cryo-Tomography

Eindhoven, Netherlands

Application deadline: 06 May 2022

When When you’re a part of Thermo Fisher Scientific, you’ll do challenging work, and be part of a team that values performance, quality and innovation. As part of a successful, growing global organization you  will be encouraged to perform at your best. With revenues of more than $35 billion and the largest investment in R&D in the industry, we give our people the resources and opportunities to make significant contributions to the world.

Location/Division Specific Information

You will be a part of the Applications Development team within the Life Sciences Business Unit (LSBU) of Thermo Fisher Scientific’s Material and Structure Analysis Division (MSD). LSBU provides high-value Electron Microscopy workflow solutions for high resolution biological imaging, ranging from atomic resolution imaging of protein complexes to volume acquisition of cellular compartment structures. The position is based in Eindhoven, Netherlands.

How will you make an impact?

You will be responsible for development of world-class methods and protocols for electron Cryo-Tomography (CryoET) workflows in Life Sciences using our state of the art Krios microscopes equipped with cold field emission gun (CFEG) and Selectris imaging filters. You will be a lead in applications development for our tomography projects with our collaborators and customers. You will collect and process tilt series datasets and perform sub-tomogram averaging analysis from purified protein samples as well as FIB milled cellular lamella. Furthermore, you will build a network within the cryoEM/ET community through collaborations with new and leading customers and help shape the future of cryoET. You will support product development and plan, own and execute applications case studies. This will require identifying relevant samples and defining new methods and protocols for cryoET workflows. 

What will you do?      

• Develop and evaluate cryoET applications with our Krios and Glacios microscopes. This will include collecting and processing high resolution datasets for CryoET from purified proteins and cellular lamella samples.
• Work with academic and industrial collaborators/customers and beta sites for training users (on site and remotely) and help demonstrate proof of concepts with challenging samples.
• Support R&D, product development, marketing, and sales by lending applications expertise.
• Communicate new applications results at scientific workshops, conferences and contribute to scientific publications.  
• Perform demonstrations on pre-release products.
• Serve as a Life Sciences cryoET expert.
• Provide feedback to engineering and software development teams on system performance, new design features, new hardware qualification and advanced use-case problems for CryoET data collection and processing.
• Deliver marketing and sales collateral to the Product Marketing group for incorporation into marketing and sales training.

How will you get here?

This position is ideal for an experienced electron microscopist with a familiarity of cryo-TEM operations, theory and technique including cryo-sample preparation, tilt series data collection and sub-tomogram averaging. You will be able to “think out of the box” and would like to be engaged in a variety of complex and creative tasks. You will enjoy training new users and solving the most difficult and advanced technical challenges in CryoET data collection and processing techniques. 

The ideal candidate will possess the following combination of education, experience and skills:

• PhD degree or equivalent in Life Sciences, Structural Biology, CryoEM, Image processing, or X-ray crystallography.
• Demonstrated experience with sample preparation for cryoTEM and knowledge of data collection and processing for sub-tomogram averaging.
• Experience interacting with new users and highly technical customers and the ability to communicate complex technical concepts to a variety of audiences.
• Demonstrated ability to systematically develop new and improved methods, protocols, troubleshooting techniques and operational optimization.
• Excellent verbal and written communication skills with a diverse audience.
• Aptitude to independently identify, define and execute solutions in a highly dynamic and ambitious environment.
  • Ability to identity opportunities (e.g. for collaborations that support product strategy)
  • Ability to own and manage a project
• Leadership: Make significant contributions to defining the framework and future direction of cryoET products.
• Training: Ability to impart application specific knowledge to new users and internal stakeholders.
• Thrives in a dynamic team, can drive product improvement, and enjoys being exposed to a constant variety of complex issues that need to be resolved.
• Willing and able to travel domestically and internationally 25%.
• Able to build a customer network within academia and pharma industry.

At Thermo Fisher Scientific, each one of our 70,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier, cleaner and safer.

 Apply today! http://jobs.thermofisher.com

 Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.