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InstructThe latest webinar in the Instruct-ERIC Structure Meets Function series this month includes speakers who have accessed cutting-edge structural biology services through Instruct. The webinar series offers an insight into the very cutting edge of structural biology research, utilising the latest techniques available through Instruct-ERIC facilities and centres.
In May, we will hear from Heikki Saari of the University of Helsinki, whose Instruct R&D project helped to generate a Raman spectroscopy tool for extracellular vesicle analysis. We will also have a talk from Carine de Marcos Lousa of the University of Dundee, who accessed X-Ray and Cryo-EM technologies at the University of Leeds and the University of Oxford through Instruct.
Speaker: Heikki Saari
Title: Instruct-FI Develops Raman Spectroscopy Tool for EV Analysis as Part of Instruct R&D Scheme
Abstract: TBC
Speaker: Carine de Marcos Lousa
Title: The Crystal Structure of Vacuolar Sorting Receptor
Abstract: Vacuolar sorting receptors (VSRs) are type I membrane proteins essential for plant development. Although their trafficking pathways have been extensively characterized, the molecular mechanisms underlying cargo recognition and release by their N-terminal lumenal domains remain poorly understood. We have elucidated the crystal structures of the lumenal region of Arabidopsis VSR1 in both cargo-free and cargo-bound states. These structures reveal the conformational changes associated with cargo binding and suggest a dynamic oligomerization mechanism that may regulate receptor function and trafficking. Our findings offer new insights into the molecular basis of VSR-mediated cargo sorting and propose a mechanistic model potentially applicable to other membrane trafficking receptors.
