Instruct-ERIC Events

Integrative methods in Structural Biology to enhance high impact research in health and disease: Montevideo

Training
Date: 16-Feb-2016

Contact: Alejandro Buschiazzo

Instruct

This event is organised by the University of Oxford, the Institute Pasteur Montevideo and Instruct in the context of the British Council "Research Links" programme funded under the Latin America Science & Innovation Fund, Which provides opportunities for early career researchers from the UK and Uruguay to interact, to learn from each other and to explore opportunities for building long-lasting research collaborations.

The workshops will provide a unique opportunity for sharing research expertise and networking. During the workshops early career researchers will have the opportunity to present their research in the form of a poster/short oral presentation and discuss this with established researchers from the UK and Uruguay. There will be a focus on building up links for future collaborations and participants selected on the basis of their research potential and ability to build longer term links.

Programme

Day 1: 16th February, 2016 - “Structural Biology and Health: Current Challenges”

This first day will include two sessions allowing for scientists from Europe and South America to present current advances on protein science and structural biology. Focus will be given to targets of relevance for health and food security in the UK and Uruguay.

Immediate health threats, be them infectious or non-communicable, as well as animal and plant health with incidence in food security, will be major issues to be addressed.

Future strategies for the development of new drugs and vaccines, where Structural Biology can contribute with novel opportunities shall be matter of discussion.

Session 1 Chairs: Alejandro Buschiazzo and Jose Maria Carazo

09.00-09.40

Alejandro Buschiazzo, Institute Pasteur Montevideo

09.40-10.20

Rafael Radi, Universidad de la Republica

10.20-10.50

Coffee

10.50-11.20

Opher Gileadi, Structural Genomics Consortium

11.20-12.00

Lisandro Otero, Fundación Insttituto Leloir

12.00-12.20

Talk selected from abstract: Kyle Dent. Diamond Light Source

12.20-13.00

Rodolfo Rasia, IBR, Rosario

13.00-14.25

Lunch

Session 2 - Chairs: Rodolfo Rasia and David Stuart

14.25-14.30 Graham Stanley, British Council

14.30-15.10

David Stuart, University of Oxford

15.10-15.50

Chuck Farah, USP, Sao Paulo

15:50-16:20

Tea

16.20-17.00

Fernando Goldbaum, Fundación Insttituto Leloir,

17.00-17.20

Talk selected from abstract : Carolina Fontana

17.20-19.20

Poster Session 1

20:00

Dinner

Day 2: 17th February, 2016

Session 3 “Emerging Technologies in Integrative Structural Biology” - Chairs: Chuck Farah and Alberto Podjarny

This session is aimed at discussing about technologies that are changing the structural biology landscape, with emphasis on high resolution cryo-electron microscopy. The integration of several complementary techniques into a 'hybrid methods' approach is allowing for a revolutionary way of imaging cells, bridging the gap between large macromolecular complex and assemblies at the cellular scale, all the way to atomistic detail of single molecular components.

09.00-09.40

Jose Maria Carazo, Madrid

09.40-10.20

Alberto Podjarny, Strasbourg

10.20-11.10

Coffee

11.10-11.40

Roberto Salinas, Sao Paulo

11.40-12.20

Rodrigo Portugal, Campinas

12.20-13.00

Richard Garratt, IFSC, Sao Carlos

13.00-14.00

Lunch

Session 4 “The joint activities and impact of UK-Uruguay integration in Structural Biology” - Chairs: Claudia Alen Amaro and Alejandro Buschiazzo

This session will look into the future towards specific potential collaborations. Break-out sessions in smaller groups will allow for participants to discuss focused on concrete questions to be proposed by the chairs. This session will close with the signing of a MOU for future integration activities between Instruct and Uruguay, and will be followed by the second and last poster session.

14.00-14.15

Dave Stuart, Oxford

14.15-14.30

Alejandro Buschiazzo, Montevideo

14.30-15.30

Break out Sessions

15.30-16.00

Tea

16.00-16.30

Report from Break out sessions

16.30-17.00

Q&A

17.00-17.30
Graham Stanley, British Council

17.30-17.45

Close of Scientific Meeting with the signing of a MOU for future integration activities between Instruct and Uruguay

– Next venue announcement

17.45-19.30

Poster Session 2

21.00

Dinner and carnival show at a traditional Uruguayan ‘Tablado’

Days 3 and 4: Hands-on Sessions “Single Particle cryo-EM and 3D reconstruction” - Tutors: Jose Maria Carazo, Josue Gomez Blanco, Rodrigo Portugal

The teaching facilities at IP Montevideo constitute an excellent platform for training in data processing and structural analyses, using cryo-EM data and quantitative fitting of crystallographic structures into EM-derived electron density maps. A teaching room with 25 dedicated computers (with NFS connection to central servers), will allow for one UK/European attendee to share problem-solving sessions with one Uruguayan/South American, enhancing interactions. The workshop will encourage students to bring in their own experimental data, but this will not be limiting: with the spirit of a kick-off meeting, people with no data will be provided with tutorial data to follow training sessions.

Day 3: 18th February, 2016 – Cryo-EM data processing

Day 4: 19th February, 2016 – Quantitative fitting of atomic models into EM density map envelopes : tools, approaches, influence of EM data resolution

Application and Deadline:

The full application must be completed and submitted by the 31st of December 2015 to secretaria@pasteur.edu.uy

Eligibility Criteria:

- Applications must be submitted using the Researcher Links application form

- Application must be submitted before the above deadline

- Applications will be accepted only from early career researchers, or from students that are enrolled in a PhD programme at the time of application. Early Career Researchers are defined as holding a PhD for less than 10 years on the starting date of the workshop, and will be given priority in the selection process.

- Participants must be affiliated to UK and Uruguay higher education or research institutions at the time of the application.

Quality Assessment

- Experience and relevance of the applicant’s research area to the workshop

- Motivation and contribution to the aims of the workshop

- Description of the long term impact expected through the participation in the workshop

- Ability to disseminate workshop’s outcomes

Selection Procedure:

- Eligibility check

- Quality assessment

- CV review

Montevideo, Uruguay

Integrative methods in Structural Biology to enhance high impact research in health and disease: Montevideo