Instruct-ERIC course and MR Latvia workshop “Modern NMR for Biomolecular Interactions: From Solution and Solid-State to Hyperpolarization and AI”

Training

Registration Date: 23-Feb-2026 to 28-Apr-2026

Date: 08-Jun-2026 to 11-Jun-2026

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Instruct Partner

This course aims to provide young researchers with a comprehensive understanding of how modern NMR spectroscopy methods can reveal the complexity of biomolecular interactions. In the theoretical part of the course, state-of-the-art biomolecule interaction NMR techniques in liquids and solids, hyperpolarization, and AI will be discussed. The hands-on sessions on NMR spectrometers will focus on probing protein-ligand interactions using 1D and 2D NMR spectra in liquids, as well as microcrystalline samples in solid-state NMR. The course tutors will demonstrate how to analyze and plot the acquired datasets to visualize protein-ligand interaction sites.

There will be limited possibilities to bring own unlabeled samples for preliminary characterization, including interactions with ligands (e.g. 1D liquid-state NMR). Bringing of own samples should be negotiated individually before course.

The number of participants for the hands-on section is limited to 12. They will be selected based on filled application.

The registration is free of charge. The accommodation is provided and travelling expenses (within Europe - up to 100 EUR based on location) are also partially compensated by the course organizers. Successful candidates will be notified by 30 April at the latest.

The course is organized in collaboration with the Horizon Europe project “Magnetic resonance development in Latvia project team (MR LATVIA)”. At the moment, the accepted tutors for the course are:

Harald Schwalbe - Goethe University, Frankfurt, Germany
Guido Pintacuda – CNRS/CRMN, Lyon, France
Roberta Pierattelli - CERM/CIRMMP, Florence, Italy
Anne Schutz - Ludwig-Maximilians-Universität München, Germany
Julien Orts - University of Vienna, Austria
Vladislav Orekhov – University of Gothenburg, Sweden
Dennis Kurzbach - University of Vienna, Austria
Alons Lends - LIOS, Latvia
Kaspars Tars - LBMC, Latvia
Linda Cerofolini - CERM/CIRMMP, Florence, Italy
Tsyr-Yan Yu - Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan

For registration and more information, please visit the course web page.
For any inquiries, please write to natalja.jarohnovica@osi.lv, alons.lends@osi.lv

Course agenda:

Morning Session 9:00 - 12:00	Day 1 8th June	Day 2 9th June	Day 3 10th June	Day 4 11th June
	Coffee	Coffee	Coffee	Coffee
	Lecture: Protein liquid-state interactions NMR	Lecture: Hyperpolarizat ion for protein liquid- state NMR	Lecture: Ultra-fast MAS bio solid-state NMR	Data Analysis from Hand on sessions
	Lecture: High field NMR liquid state	Lecture: RNA/DNA NMR	Lecture: High field DNP for bio solid state NMR	Lecture: AI applications for bioNMR
Lunch Break 12:00 – 13:00
Afternoon Session 13:00 - 17:00	Keynote Lecture: Real life NMR applications for drug candidate discoveries	Lecture: Isotope labeling schemes for NMR	Lecture: Bio solidstate NMR for interactions	Lecture: Protein dynamics
		Lecture: Isotope labeling schemes for NMR	Lecture: Bio solidstate NMR for interactions	Lecture: Paramagnetic NMR for drug discovery
	Hands on: Practical liquid- state/solid state NMR	Lecture: Isotope labeling schemes for NMR	Hands on: Practical liquid- state/solid state NMR	MR LATVIA platform introduction
	Hands on: Practical liquid- state/solid state NMR	Lecture: Isotope labeling schemes for NMR	Hands on: Practical liquid- state/solid state NMR	Wrap up and discussion about future of NMR for biomolecular interactions
Evening	Free Time	Free Time	Free Time	Free Time
Evening	Free Time	Dinner	Dinner	Joint Dinner

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