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We are pleased to announce our next webinar in the DRIIMB Webinar series by Prof. Alexandre Bonvin, Utrecht University.
Title: Solving 3D puzzles of biomolecular interactions by physics- and AI-based integrative modelling
Date & Time: Wednesday, 29 April, 15:00–16:00 (UK time)
Platform: Microsoft Teams - click here to register
Abstract
"Understanding the structure, interactions, and dynamics of biomolecular macromolecules is key to unravelling cellular processes and advancing drug discovery. Accurate modelling of these complexes benefits greatly from incorporating diverse sources of experimental or predictive information. To this end, we have developed HADDOCK (https://www.bonvinlab.org/software), a versatile integrative modelling platform available as a web service (https://wenmr.science.uu.nl). HADDOCK can seamlessly combine data from biochemical, biophysical, and bioinformatics approaches to improve both sampling and scoring of biomolecular assemblies.
Over more than two decades of continuous development, we have also witnessed the transformative rise of AI in structure prediction. While AI has made remarkable progress, physics-based modelling remains essential, with many challenges still requiring their complementary strengths. In this talk, I will present recent advances in HADDOCK and showcase its applications, including examples where AI-generated predictions are combined with physics-based integrative modelling. In particular, I will highlight studies on antibody and nanobody–antigen complexes, demonstrating the synergy between AI and physics-based approaches. ” - Alexandre Bonvin
Speaker Bio
Alexandre Bonvin is a professor of Computational Structural Biology and the scientific director of the Bijvoet Centre for Biomolecular Research at Utrecht University. Bonvin researches how biomolecules interact with each other. Biomolecules such as proteins, nucleic acids and lipids are essential to all living organisms. In his research, Bonvin tries to uncover the social life of proteins, or how they recognise each other in order to carry out their work. The form of the proteins plays an important role in this, and these can only be researched using advanced computer models.
Announcements for all DRIIMB webinars are available at ccpbiosim.ac.uk, and recordings of previous talks can be found on the CCPBioSim YouTube channel.
