This workshop will provide an overview of the development of structural solution projects using CCP4 Cloud, a modern interface for the CCP4 Software Suite. CCP4 Cloud includes tasks for all stages of computational structure determination and provides seamless access to relevant web resources such as PDB, UniProt, AlphaFold, ESM, and third party software such as Global Phasing's Buster and NKI's PDB-REDO, Amsterdam.It offers a comprehensive suite of automated tools for image processing, phasing, model building, refinement, validation, and preparation for deposition in the PDB. The hallmark of CCP4 Cloud is its ability to automatically develop structure solution projects capable of delivering complete solutions, while allowing user intervention when a satisfactory result is not achieved.
During this workshop, attendees will be introduced to the advanced features of CCP4 Cloud, learning the powerful tools and workflows available for structure determination. We will focus on advanced techniques such as Molecular Replacement using AlphaFold-2 models, automated approaches to structural solution and project development.
