Instruct-ERIC webinar series: structure meets function
Featuring expert speakers from Instruct Centres across Europe, this webinar series highlights some of the latest developments in structural biology, demonstrating how integrative methods are enabling scientists to decipher the mechanisms that underpin health and disease.
Webinar #36 Instruct-LT | 19 Nov 2024
Speaker: Dr. Giedrius Sasnauskas
Talk Title: Cryo-EM studies of Cas12 family nucleases
Speaker: Monika Jasnauskaitė
Talk Title: Structure and mechanism of the anti-phage defense system retron Ec67
Speaker: Dr. Giedrė Tamulaitienė
Talk Title: Structural studies of bacterial antiviral defense system Thoeris
Webinar #35 ISIDORe | 15 Oct 2024
Moderator: Pauline Audergon
Speaker: Acha Nelson Lekeayi - University of Buea
Title: In-silico design and serological characterization of a novel multiepitope antigen as a potential candidate for human monkeypox sero-surveillance in the South West Region of Cameroon
Speaker: George Vavougios - University of Cyprus
Title: Serum proteomic and exosome tau overlap between Alzheimer’s disease and PACS / Long COVID and its cognitive correlates
Webinar #34 Fragment-Screen | 17 Sept 2024
Moderator: Irene Sanchez Lopez
Speaker 1: Jiri Novacek - CEITEC
Speaker 2: Elda Bauda - University of Geneva
Webinar #33 Fragment-Screen | 16 July 2024
Moderator: Fragment-Screen Team
Speaker 1: Genevieve Evans - EMBL-EBI
Speaker 2: Jannis Born - IBM Research
Webinar #32 ISIDORe | 17 April 2024
Moderator: Marylène Vandevenne, Robotein
Speaker 1: Nikitas Georgiou - National and Kapodistrian University of Athens
Speaker 2: Séverine Padiolleau - Université de Technologie de Compiègne
Webinar #31 IBS Grenoble | 19 March 2024
Moderator: Martin Blackledge, IBS Grenoble
Speaker 1: Vincent Chaptal, IBCP Lyon
Speaker 2: Barbara Zambelli, University of Bologna
Webinar #30 AI and Machine Learning | 13 February 2024
Speaker 1: Beatriz Serrano-Solano, AI4Life
Speaker 2: Tiago Rodrigues, FF Ulisboa
Speaker 3: Enara Vijil, IBM
Webinar #29 Instruct-FR1 | 23 January 2024
Speaker 1: Katia Zanier - Université de Strasbourg
Title: Mechanism of IKK kinase-substrate docking in NF-kB signaling
Speaker 2: Konstantin Brodolin - Université de Montpellier
Title: Regulation of transcription via RNA polymerase oligomerization
Webinar #28 Instruct-FI | 17 October 2023
Moderator: Janne Janis, University of Eastern Finland
Talk 1: Ilona Rissanen, University of Helsinki
Title: Structure meets potency: Insights into effective SARS-CoV-2 inhibition
Talk 2: Giovanna Viola, University of Verona
Title: Investigating the influence of ubiquitination on the conformational propensities of the amyloidogenic Tau protein by mass spectrometry methods
Webinar #27 Instruct-BE and EMBL | 13 June 2023
Moderator: Maria Garcia, EMBL
Talk 1: Daphnée Georges, ULB & ULiège, BE
Title: High throughput assay for IgG avidity determination in the context of SARS-CoV-2 infection and/or vaccination
Talk 2: Maria Dimarogona, University of Patras, GR
Title: Structural insights into carbohydrate-active enzymes for the design of plastic degrading biocatalysts
Talk 3: Leonardo Alonso, University of Buenos Aires, AR
Title: Behind the functional role of asparagine deamidation in coronavirus proteins
Register for the Webinar here.
Webinar #26 New Instruct Technologies | 16 May 2023
Speaker 1: Javier Conesa
Speaker 2: David Herreros
Talk Title: Introduction to CNB-CSIC CLEM, and I2PC FlexiHub.
Speaker 3: Alexandre Durand
Speaker 4: Catherine Birck
Talk Title: Introduction to IGBMC Chameleon and BLI/FIDA.
Webinar #25 Instruct-CZ Users | 14 March 2023
Moderator: Jan Dohnalek
Speaker: Tibor Fuzik
Talk Title: Structure of tick-borne encephalitis virus immature particle solved by cryo-electron microscopy and sub-tomogram averaging
Speaker: Ondrej Vanek
Talk Title: Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse
Webinar #24 Special Edition: Instruct Access Provision | 14 February 2023
Moderator: Josan Marquez
Speaker: Simone Di Micco, EBRIS
Talk Title: Design and structural insights of new zonulin inhibitor Larazotide (AT1001) derivatives as potential anti SARS-CoV-2.
Speaker: Felipe Trajtenberg, IP Montevideo
Talk Title: Allostery in bacterial two-component signaling systems: building efficient information processing machines
Speaker: Alejandro Buschiazzo, IP Montevideo
Talk Title: An asymmetric structure of the filament is key to inducing flagellar curvature and enabling motility in the Leptospira spirochete
Webinar #23 Special Edition: Instruct partner in Latin America | 13 December 2022
Moderator Ana Zeri
Speaker: Leticia Llarrull, IBR-CONICET
Talk Title: Advances in structural and functional characterization of the sensor/transducer MecR1 protein of Staphylococcus aureus
Speaker: Alejandro Vila, IBR-CONICET
Talk Title: In-cell kinetic stability is an essential trait in protein evolution: the case of Metallo-beta-lactamases
Register and join the webinar here.
Webinar #22 Special Edition: Instruct partner in Latin America | 12 October 2022
Moderator Natalia Lisa
Speaker: Richard Garratt, University of Sao Paulo
Talk Title: Protein crystallography off the beaten track: Septins, their filaments and the importance of access to research infrastructure
Speaker: Italo Cavini, University of Sao Paulo
Talk Title: The versatile septin coiled-coil domains
Webinar #21 Special Edition | 6 September 2022
Moderator Rolf Boelens
Speaker: Markus Weingarth, Bijvoet Centre, Utrecht University
Talk Title: Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Webinar #20 Instruct UK - 7 June 2022
Talk 1: Understanding the mechanism of the bifurcating hydrogenase from Thermotoga maritima through the application of cryoEM and symmetry expansion
Speaker: Jamie Blaza, Universiti of York
Talk 2: Structure and mechanism of action of Vip3 toxins
Speaker: Colin Berry, Cardiff University
Webinar #19 Instruct Spain - 10 May 2022
Talk 1: Characterisation of the Chikungunya virus nsP1 RNA capping pathway using the cryoEM facilities at Instruct CNB
Speaker: Rhian Jones
Talk 2: From Structure to Function and Back - identifying a medically crucial membrane protein by CryoEM
Speaker: Simone Weyand
Talk 3: Visualizing key regulatory allosteric mechanisms in bacterial glycogen biosynthesis
Speaker: Javier Cifuente
Webinar #18 Instruct Netherlands - 12 April 2022
Duration: 1 hour 30 minutes
Talk 1: A Real-Time Approach to Study Cellular Metabolism in Hepatocytes
Speaker: Simone Fjordside
Talk 2: Reconstituting the 2D world of signalling proteins – exploring the role of membrane topography for information transfer
Speaker: Kristina Ganzinger
Talk 3: Structure of a proteo-lipidic viral tail-tube for viral genome delivery
Speaker: Nicola Abrescia
Webinar #17 Instruct Italy - 15 March 2022
Duration: 1 hour
Talk 1: Characterization of the intrinsically disordered region of human N-myc downstream regulated gene-1, a possible target for lung cancer therapy
Speaker: Barbara Zambelli
Talk 2: Novel interaction between the key mitochondrial oxidoreductase Mia40 and the major thiol peroxidase Gpx3
Speaker: Kostas Tokatlidis
Webinar #16 Instruct Israel - 8 Feb 2022
Duration: 1 hour
Talk 1: SARS-CoV-2 Omicron prediction and antiviral drug design are enabled by RBD in vitro evolution
Speaker: Gideon Schreiber
Talk 2: AlphaFold and protein optimisation
Speaker: Shiran Barber-Zucker
Webinar #15 Instruct Portugal - 14 Dec 2021
Video Duration: 1 hour
Webinar Moderator: Maria Arménia Carrondo, Universidade Nova de Lisboa
Talk 1: Exploring a new drug target against Mycobacterium tuberculosis
Speaker: Hugo Fraga
Talk 2: Breaking the limits of native MS with MRMS
Speaker: Carlos Cordeiro
Talk 3: Catching up with the CryoEM Resolution Revolution
Speaker: Pedro Matias
Webinar #14 Instruct Lithuania - 16 Nov 2021
Duration: 1 hour 13 minutes
Talk 1: Biomembranes on a chip: tethered phospholipid bilayers for protein membrane interaction studies
Speaker: Gintaras Valinčius
Talk 2: Bacterial immunity: from restriction enzymes to CRISPR
Speaker: Virginijus Šikšnys
Webinar #13 Instruct Slovakia - 12 Oct 2021
Duration: 1 hour 06 minutes
Talk 1: Interpreting Single-Molecule Force Spectroscopy Experiments with Normal Mode Analysis
Speaker: Jacob Bauer
Talk 2: Mass Spectrometry in Glycoproteomic Analyses
Speaker: Zuzana Pakanová
Talk 3: Development of single-molecule protein biophysics
Speaker: Gabriel Žoldák
Webinar #12 Instruct Latvia - 14 Sept 2021
Duration: 1 hour 20 minutes
Talk 1: ssRNA phages – structural studies and applications of their virus-like particles
Speaker: Kaspars Tars
Talk 2: Structural and functional insights into GRM2 type choline degrading type bacterial microcompartments
Speaker: Gints Kalnins
Talk 3: Spider silk: from NMR structural studies to mechanism of formation and artificial fibres
Speaker: Kristaps Jaudzems
Webinar #11 Instruct Centre FR2 - 08 June 2021
Duration: 1 hour 12 minutes
Talk 1: DC-SIGN and L-SIGN receptors from immune cells recognize spike glycoprotein and promote SARS CoV-2 trans infection
Speaker: Franck Fieschi
Talk 2: Photoenzyme at work: Structural dynamics of fatty acid photodecarboxylase
Speaker: Martin Weik
Talk 3: The high resolution cryo-EM structure of full-length La Crosse virus polymerase reveals functionally important conformational changes
Speaker: Helene Malet
Webinar #10 Instruct Centre FR1 - 12 May 2021
Duration: 1 hour 21 minutes
Talk 1: Structural basis for the allosteric regulation of Human Topoisomerase 2α
Speaker: Valérie Lamour
Talk 2: Structure of the SAGA transcriptional co-activator
Speaker: Gabor Papai
Talk 3: Structural basis of transcription translation coupling and collision in bacteria
Speaker: Albert Weixlbaumer
Webinar #9 Instruct Centre FI - 13 April 2021
Duration: 1 hour 13 minutes
Talk 1: Biocomplex: Sample preparation strategies for biomolecular complexes
Speaker: Minna Poranen
Talk 2: Switching on ADP-ribosylation at the DNA damage site
Speaker: Lari Lehtiö
Talk 3: High-resolution native mass spectrometry as a versatile tool in structural biology
Speaker: Juha Rouvinen
Webinar #8 Instruct Centre EMBL - 16 March 2021
Duration: 1 hour 18 minutes
Talk 1: In-situ structural analysis of SARS-CoV-2 spike protein using subtomogram averaging and molecular dynamics
Speaker: Beata Turonova
Talk 2: Structural analysis of COVID-19-related molecules at EMBL Hamburg
Speaker: Dmitri Svergun
Talk 3: Online crystallography: Automated pipelines for protein crystallography and drug design
Speaker: Jose A. Marquez
Webinar #7 Instruct Centre CZ - 17 February 2021
Duration: 1 hour 18 minutes
Talk 1: Enterovirus genome release and delivery
Speaker: Pavel Plevka
Talk 2: Sweeping RNA polymerase - role of protein HelD in bacterial transcription
Speaker: Jan Dohnálek
Talk 3: Probing structures and interactions of nucleic acids in living human cells using NMR Spectroscopy
Speaker: Lukáš Trantírek
Webinar #6 Instruct Centre BE - 12 January 2021
Duration: 1 hour 35 minutes
Talk 1: Curli – structure, function and application of a bacterial amyloid pathway
Speaker: Han Remaut
Talk 2: Protein formulation through automated screening of pH and buffer conditions using the Robotein® high throughput facility
Speaker: Andre Matagne
Webinar #5 Instruct Centre UK - 15 December 2020
Webinar #4 Instruct Centre Spain - 10 November 2020
Duration: 1 hour 9 minutes
Talk 1: Beyond static structural models: Analysis of continuous protein flexibility by Cryo-EM and its application to SARS-CoV-2
Speaker: José María Carazo and Marta Martinez
Talk 2: An image processing pipeline for SARS-CoV-2 Cryo-EM: a single method is not enough
Speaker: Carlos Óscar Sánchez Sorzano
Talk 3: Integrating structural information and biomedical annotations: 3DBionotes-Covid19 Portal
Speaker: José Ramón Macías
Webinar #3 Instruct Centre Netherlands - 13 October 2020
Duration: 1 hour 16 minutes
Talk 1: Protein structure and interactions control contacts in the nervous system
Speaker: Bert Janssen
Talk 2: High-resolution NMR of antibiotics in the native state
Speaker: Markus Weingarth
Talk 3: Cryo-EM structures reveal the selection process for DNA mismatch repair initiation
Speaker: Meindert Lamers
Webinar #2 Instruct Centre Italy - 18 September 2020
Duration: 1 hour 9 minutes
Talk 1: Drug screening by in-cell NMR
Speaker: Enrico Luchinat
Talk 2: 1.2 GHz NMR applied to Sars-CoV2 proteins
Speaker: Francesca Cantini
Talk 3: SS NMR of functionalised biomaterials
Speaker: Marco Fragai
Webinar #1 Instruct Centre Israel - 18 August 2020
Duration: 1 hour 6 minutes
Talk 1: Crowdsourcing for SARS-CoV-2 Mpro inhibitor - a global effort driven by structural biology
Speaker: Dr Nir London
Talk 2: Line-FRAP, a method to measure diffusion rates of a large range of molecules in vitro and in vivo
Speaker: Prof Gideon Schreiber
